Linked Life Data

9083087

Source:http://linkedlifedata.com/resource/pubmed/id/9083087

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1997-5-8
pubmed:abstractText
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are structurally and functionally related cytokines which play an important role in the regulation of the immune response to infection. The functional similarity of IL-4 and IL-13 can be explained, at least in part, by the common components that form their cell surface receptors, namely the IL-4 receptor alpha-chain (IL-4Ralpha) and the IL-13 receptor alpha-chain (IL-13Ralpha). Soluble forms of the IL-4Ralpha have also been described and implicated in modulating the effect of IL-4. In this paper we describe the presence of a 45,000-50,000 Mr IL-13-binding protein (IL-13BP) in the serum and urine of mice. This protein binds IL-13 with a 100-300-fold higher affinity (KD = 20-90 pM) than does the cloned IL-13Ralpha (KD = 3-10 nM). In addition to this functional difference, the IL-13BP appears to be structurally and antigenically distinct from the IL-13Ralpha. Finally, unlike the cloned receptor, the IL-13BP acts as a potent inhibitor of IL-13 binding to its cell surface receptor, raising the possibility that it may be used to modulate the effects of IL-13 in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9474-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9083087-Animals, pubmed-meshheading:9083087-Antigens, CD, pubmed-meshheading:9083087-Chromatography, Affinity, pubmed-meshheading:9083087-Chromatography, Gel, pubmed-meshheading:9083087-Cloning, Molecular, pubmed-meshheading:9083087-Electrophoresis, Polyacrylamide Gel, pubmed-meshheading:9083087-Glycosylation, pubmed-meshheading:9083087-Interleukin-13, pubmed-meshheading:9083087-Interleukin-13 Receptor alpha1 Subunit, pubmed-meshheading:9083087-Interleukin-4, pubmed-meshheading:9083087-Mice, pubmed-meshheading:9083087-Molecular Weight, pubmed-meshheading:9083087-Rabbits, pubmed-meshheading:9083087-Receptors, Interleukin, pubmed-meshheading:9083087-Receptors, Interleukin-13, pubmed-meshheading:9083087-Receptors, Interleukin-4, pubmed-meshheading:9083087-Serine Endopeptidases
pubmed:year
1997
pubmed:articleTitle
Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains.
pubmed:affiliation
Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, P.O. Royal Melbourne Hospital, Victoria 3050, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't