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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-4-3
|
| pubmed:abstractText |
This study was conducted to determine whether the storage conditions and the levels of psyllium in the diet modulate its hypocholesterolemic effects. Seventy-five male Sprague-Dawley rats, age 90 d, were randomly divided into five treatment groups and were fed cholesterol-containing diets for 21 d. Diets included 10% cellulose (control); 5 or 10% psyllium stored 8 mo at 5 degrees C (PS5); or 5 or 10% psyllium stored 8 mo at 40 degrees C (PS40). The higher storage temperature caused a gradual decrease in molecular weight of the psyllium, as measured by changes in solution viscosity. Hepatic rates of sterol synthesis were significantly (P < 0.001) higher in all of the psyllium-fed rats compared with control rats [21 +/- 2, 312 +/- 35, 464 +/- 40, 328 +/- 49 and 439 +/- 57 nmol [3H]digitonin-precipitable sterol (DPS)/(g liver x h), respectively, for control, 5% PS5, 10% PS5, 5% PS40 and 10% PS40]. A similar trend was observed in intestinal rates of sterol synthesis, and the difference was significant (P < 0.05) for all treatment groups except the 5% PS5-fed group compared with the control group. Liver total cholesterol and total lipid concentrations were significantly lower in all psyllium-fed rats compared with controls. There were no significant differences in serum total cholesterol concentrations among the psyllium-fed groups, although serum cholesterol levels in both the PS5-fed groups were significantly (P < 0.05) lower than that in the control group (2.66 +/- 0.18, 2.62 +/- 0.15 and 3.26 +/- 0.12 mmol/L, respectively, for 5% PS5, 10% PS5 and control). Serum triglyceride and HDL cholesterol concentrations did not vary significantly among groups. The findings of this study indicate that the cholesterol-lowering activity of psyllium is unaltered by storage conditions shown to cause a moderate degree of hydrolysis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-3166
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
127
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
463-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9082031-Animals,
pubmed-meshheading:9082031-Cholesterol,
pubmed-meshheading:9082031-Cholesterol, Dietary,
pubmed-meshheading:9082031-Drinking,
pubmed-meshheading:9082031-Eating,
pubmed-meshheading:9082031-Food Preservation,
pubmed-meshheading:9082031-Hydrolysis,
pubmed-meshheading:9082031-Intestine, Small,
pubmed-meshheading:9082031-Liver,
pubmed-meshheading:9082031-Male,
pubmed-meshheading:9082031-Molecular Weight,
pubmed-meshheading:9082031-Organ Size,
pubmed-meshheading:9082031-Plantago,
pubmed-meshheading:9082031-Plants, Medicinal,
pubmed-meshheading:9082031-Psyllium,
pubmed-meshheading:9082031-Random Allocation,
pubmed-meshheading:9082031-Rats,
pubmed-meshheading:9082031-Rats, Sprague-Dawley,
pubmed-meshheading:9082031-Temperature,
pubmed-meshheading:9082031-Triglycerides,
pubmed-meshheading:9082031-Viscosity,
pubmed-meshheading:9082031-Weight Gain
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Native and partially hydrolyzed psyllium have comparable effects on cholesterol metabolism in rats.
|
| pubmed:affiliation |
University of Illinois at Chicago, 60612, USA.
|
| pubmed:publicationType |
Journal Article
|