Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1977-11-30
|
| pubmed:abstractText |
The purpose of this investigation was to determine whether prior induction of a non-specific delayed reaction at a site of leishmanial infection could modify the course of infection. Groups of animals were made hypersensitive to either DNCB or BCG and a delayed reaction was elicited by corresponding antigen in one or both ears when an infective dose of L. enriettii was inoculated. With various experimental designs the following results were obtained: (a) induction of delayed reaction by DNCB or BCG inhibited the development of leishmanial lesions; (a) the protection was effective only when delayed reaction occurred at the site of infection; (c) to be effective, the reaction had to be continuously present at the site of infection for at least 3--4 weeks; (d) lesions developed normally, in the absence of delayed reaction, in DNCB-tolerant animals treated with DNCB; (E) a protective delayed reaction did not completely eliminate the parasites from the host tissues, since metastatic lesions appeared later at ectopic areas; (f) the suppressed development of a lesion did not confer resistance to reinfection dose of the parasite. It is concluded that cell-mediated immunity plays an important role in healing leishmanial lesions in the guinea-pig and that the final effector mechanism may be sought in the non-specific microbicidal capacity of activated macrophages. The relevance of leishmania-specific delayed reaction in the course of the disease is discussed.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4249071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4275846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4403487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4469216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4619359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4619589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4945362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-4994126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-5568123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-5885827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-765014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/908177-813928
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0009-9104
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
320-5
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:908177-Animals,
pubmed-meshheading:908177-Antigens,
pubmed-meshheading:908177-BCG Vaccine,
pubmed-meshheading:908177-Dinitrochlorobenzene,
pubmed-meshheading:908177-Guinea Pigs,
pubmed-meshheading:908177-Hypersensitivity, Delayed,
pubmed-meshheading:908177-Immunity, Cellular,
pubmed-meshheading:908177-Leishmaniasis
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Mechanisms of protective immunity in experimental cutaneous leishmaniasis of the guinea-pig. III. Inhibition of leishmanial lesion in the guinea-pig by delayed hypersensitivity reaction to unrelated antigens.
|
| pubmed:publicationType |
Journal Article
|