Linked Life Data

9078432

Source:http://linkedlifedata.com/resource/pubmed/id/9078432

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-27
pubmed:abstractText
Using replication-deficient retrovirus to transfer marker genes into immature cells, we have characterized spatial and temporal patterns of glial progenitor migration and differentiation in the early postnatal rat forebrain and cerebellum, and interneuron differentiation in the cerebellum. Progenitors do not migrate randomly, but follow discrete paths, largely confined to a coronal plane in forebrain and a sagittal plane in cerebellum. Radial glia provide one substrate for migration. In vitro studies suggest that radial glia contribute a permissive pathway along which progenitors in an immature, migratory state. Local environmental cues that progenitors encounter during migration may influence fate decisions substantially. Not all progenitors differentiate; some remain in an immature, proliferative state in which they do not complete differentiation, but can be induced to do so by pathological conditions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0378-5866
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Fate determination and migration of progenitors in the postnatal mammalian CNS.
pubmed:affiliation
Department of Pathology, Columbia University, College of P&S, New York 10032, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review