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rdf:type |
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lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0035820,
umls-concept:C0205224,
umls-concept:C0242613,
umls-concept:C0332307,
umls-concept:C0871261,
umls-concept:C1337104,
umls-concept:C1416479,
umls-concept:C1552644,
umls-concept:C1704632,
umls-concept:C1706474,
umls-concept:C1706817,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2603343,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1997-5-15
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pubmed:abstractText |
Interferons (IFNs) are a class of cytokines which confer cellular resistance against viral infections. Type I (IFN-alpha and -beta) and type II (IFN-gamma) IFNs utilize distinct receptors, the stimulation of which results in the induction of downstream target genes. These target genes usually contain within their promoter region an IFN responsive element, termed ISRE (IFN stimulated response element) which binds a heterotrimeric transcription factor, ISGF3 (IFN-stimulated gene factor 3) consisting of p48 (ISGF3 gamma), Stat1 (Signal transducers and activators of transcription-1; alpha or beta), and Stat2. The ISRE sequence overlaps with that of IRF-E which binds another IFN-inducible factor, IRF-1 (IFN regulatory factor-1).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IRF9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-Stimulated Gene Factor 3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-Stimulated Gene Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Irf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Isgf3g protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1356-9597
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pubmed:author |
pubmed-author:HaradaHH,
pubmed-author:KadokawaYY,
pubmed-author:KashiwazakiYY,
pubmed-author:KimuraTT,
pubmed-author:MaoT STS,
pubmed-author:MatsumotoMM,
pubmed-author:MatsuyamaTT,
pubmed-author:NoguchiSS,
pubmed-author:SatoMM,
pubmed-author:TakasugiTT,
pubmed-author:TanR SRS,
pubmed-author:TaniguchiTT,
pubmed-author:TarutaniMM
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-24
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9078371-Animals,
pubmed-meshheading:9078371-Antiviral Agents,
pubmed-meshheading:9078371-Base Sequence,
pubmed-meshheading:9078371-DNA,
pubmed-meshheading:9078371-DNA Primers,
pubmed-meshheading:9078371-DNA-Binding Proteins,
pubmed-meshheading:9078371-Gene Targeting,
pubmed-meshheading:9078371-Humans,
pubmed-meshheading:9078371-Interferon Regulatory Factor-1,
pubmed-meshheading:9078371-Interferon Type I,
pubmed-meshheading:9078371-Interferon-Stimulated Gene Factor 3,
pubmed-meshheading:9078371-Interferon-Stimulated Gene Factor 3, gamma Subunit,
pubmed-meshheading:9078371-Interferon-gamma,
pubmed-meshheading:9078371-Mice,
pubmed-meshheading:9078371-Mice, Knockout,
pubmed-meshheading:9078371-Phosphoproteins,
pubmed-meshheading:9078371-Transcription Factors
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pubmed:year |
1996
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pubmed:articleTitle |
Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.
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pubmed:affiliation |
Department of Immunology, Faculty of Medicine, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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