rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1997-6-5
|
pubmed:abstractText |
The hepatic transport of bile salts can be regulated by changes in bile salt pool size and/or in the flux of bile salts through the liver. Prolonged bile salt pool depletion is associated with down-regulation of maximum taurocholate transport and decreased canalicular membrane specific bile salt binding sites. This study was undertaken to investigate: a) whether adaptive down-regulation of maximum hepatic bile salt transport occurs to the same extent for bile acids of different hydrophobicity; and b) the role of microtubule-dependent vesicular pathway in the adaptive changes of bile salt transport capacity.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0168-8278
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
694-702
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9075679-Adaptation, Biological,
pubmed-meshheading:9075679-Animals,
pubmed-meshheading:9075679-Bile Acids and Salts,
pubmed-meshheading:9075679-Biological Transport,
pubmed-meshheading:9075679-Cholagogues and Choleretics,
pubmed-meshheading:9075679-Down-Regulation,
pubmed-meshheading:9075679-Endocytosis,
pubmed-meshheading:9075679-Horseradish Peroxidase,
pubmed-meshheading:9075679-Liver,
pubmed-meshheading:9075679-Male,
pubmed-meshheading:9075679-Microtubules,
pubmed-meshheading:9075679-Organ Size,
pubmed-meshheading:9075679-Polyethylene Glycols,
pubmed-meshheading:9075679-Rats,
pubmed-meshheading:9075679-Rats, Sprague-Dawley,
pubmed-meshheading:9075679-Taurochenodeoxycholic Acid
|
pubmed:year |
1997
|
pubmed:articleTitle |
Adaptive regulation of hepatic bile salt transport: role of bile salt hydrophobicity and microtubule-dependent vesicular pathway.
|
pubmed:affiliation |
Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|