| pubmed-article:9071432 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0027361 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0205127 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0376705 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0086589 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0023981 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:9071432 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:9071432 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9071432 | pubmed:dateCreated | 1997-7-15 | lld:pubmed |
| pubmed-article:9071432 | pubmed:abstractText | The temporal relationship between viral and surrogate markers and clinical status was analyzed prospectively every 8 weeks in 34 asymptomatic HIV-1-infected persons. After 3 years, 25 persons remained clinically healthy whereas 9 persons showed clinical progression. In accordance with other reports we found that at study entry HIV-RNA load was predictive of clinical progression. All markers tested evolved significantly in time in both progressors and nonprogressors. The HIV RNA load in plasma and HIV DNA load in T cells were linearly related only in nonprogressors. In addition, the RNA/DNA ratio during follow-up was significantly higher in progressors, indicating a higher replication rate in progressors. The HIV DNA load correlated inversely with CD4+ T cell counts and positively with p24 antigenemia in both nonprogressors and progressors. A significant correlation of HIV DNA load with SI phenotype occurred in progressors only. HIV RNA levels correlated with beta 2-microglobulin level and with p24 antigenemia but not with SI phenotype. These three markers can all routinely be measured in plasma; however, only the HIV RNA levels appear to be informative for clinical progression. Six to 8 months before clinical progression, an SI phenotype switch, increased HIV RNA in plasma, and decreased CD4+ T cell counts were all indicative of an impending clinical event. | lld:pubmed |
| pubmed-article:9071432 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9071432 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9071432 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9071432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9071432 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9071432 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9071432 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9071432 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:De VriesEE | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:HuismanJ GJG | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:KoosLL | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:FrissenP HPH | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:HarriganP RPR | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:BruistenS MSM | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:WeigelH MHM | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:LarderBB | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:Van SwietenPP | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:HenrichsJ HJH | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:KinghornII | lld:pubmed |
| pubmed-article:9071432 | pubmed:author | pubmed-author:RegezR MRM | lld:pubmed |
| pubmed-article:9071432 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9071432 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9071432 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:9071432 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9071432 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9071432 | pubmed:pagination | 327-35 | lld:pubmed |
| pubmed-article:9071432 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9071432 | pubmed:meshHeading | pubmed-meshheading:9071432-... | lld:pubmed |
| pubmed-article:9071432 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9071432 | pubmed:articleTitle | Prospective longitudinal analysis of viral load and surrogate markers in relation to clinical progression in HIV type 1-infected persons. | lld:pubmed |
| pubmed-article:9071432 | pubmed:affiliation | Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:9071432 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9071432 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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