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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-7-15
|
| pubmed:abstractText |
The temporal relationship between viral and surrogate markers and clinical status was analyzed prospectively every 8 weeks in 34 asymptomatic HIV-1-infected persons. After 3 years, 25 persons remained clinically healthy whereas 9 persons showed clinical progression. In accordance with other reports we found that at study entry HIV-RNA load was predictive of clinical progression. All markers tested evolved significantly in time in both progressors and nonprogressors. The HIV RNA load in plasma and HIV DNA load in T cells were linearly related only in nonprogressors. In addition, the RNA/DNA ratio during follow-up was significantly higher in progressors, indicating a higher replication rate in progressors. The HIV DNA load correlated inversely with CD4+ T cell counts and positively with p24 antigenemia in both nonprogressors and progressors. A significant correlation of HIV DNA load with SI phenotype occurred in progressors only. HIV RNA levels correlated with beta 2-microglobulin level and with p24 antigenemia but not with SI phenotype. These three markers can all routinely be measured in plasma; however, only the HIV RNA levels appear to be informative for clinical progression. Six to 8 months before clinical progression, an SI phenotype switch, increased HIV RNA in plasma, and decreased CD4+ T cell counts were all indicative of an impending clinical event.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0889-2229
|
| pubmed:author |
pubmed-author:BruistenS MSM,
pubmed-author:De VriesEE,
pubmed-author:FrissenP HPH,
pubmed-author:HarriganP RPR,
pubmed-author:HenrichsJ HJH,
pubmed-author:HuismanJ GJG,
pubmed-author:KinghornII,
pubmed-author:KoosLL,
pubmed-author:LarderBB,
pubmed-author:RegezR MRM,
pubmed-author:Van SwietenPP,
pubmed-author:WeigelH MHM
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
327-35
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9071432-Adult,
pubmed-meshheading:9071432-CD4 Lymphocyte Count,
pubmed-meshheading:9071432-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9071432-Disease Progression,
pubmed-meshheading:9071432-Follow-Up Studies,
pubmed-meshheading:9071432-HIV Core Protein p24,
pubmed-meshheading:9071432-HIV Infections,
pubmed-meshheading:9071432-HIV-1,
pubmed-meshheading:9071432-Humans,
pubmed-meshheading:9071432-Longitudinal Studies,
pubmed-meshheading:9071432-Matched-Pair Analysis,
pubmed-meshheading:9071432-Middle Aged,
pubmed-meshheading:9071432-Predictive Value of Tests,
pubmed-meshheading:9071432-Prospective Studies,
pubmed-meshheading:9071432-RNA, Viral,
pubmed-meshheading:9071432-Time Factors,
pubmed-meshheading:9071432-beta 2-Microglobulin
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Prospective longitudinal analysis of viral load and surrogate markers in relation to clinical progression in HIV type 1-infected persons.
|
| pubmed:affiliation |
Department of Clinical Viro-Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|