Linked Life Data

9070740

Source:http://linkedlifedata.com/resource/pubmed/id/9070740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-6-10
pubmed:abstractText
The cellular transcription factor Fos, product of the immediate early gene c-fos, is induced in secretory neurons of the hypothalamic paraventricular nucleus in response to stress. Recent evidence indicates that the paracrine-acting messenger molecule nitric oxide may be involved in the activation or regulation of c-fos expression in neurons, and many neurons in the paraventricular nucleus contain the enzyme nitric oxide synthase. Furthermore, nitric oxide has been implicated in the regulation of corticotropin-releasing factor and arginine vasopressin release from neurons of the paraventricular nucleus. To study whether nitric oxide is involved in stress activation of c-fos expression in the paraventricular nucleus, we assessed the effect of treatment with competitive nitric oxide synthase blockers on expression of Fos protein in neurons of the paraventricular nucleus of rats subjected to immobilization stress. We found that such treatment blocks stress-induced Fos expression in the paraventricular nucleus. Furthermore, using double staining for Fos and the nitric oxide synthase histochemical marker, nicotinamide adenine dinucleotide phosphatediaphorase, we found that many neurons in the paraventricular nucleus that express Fos in response to immobilization stress also contain nitric oxide synthase. These results indicate that nitric oxide is involved in the regulation of Fos expression in stress-activated cells of the paraventricular nucleus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
623-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Blockers of nitric oxide synthase inhibit stress activation of c-fos expression in neurons of the hypothalamic paraventricular nucleus in the rat.
pubmed:affiliation
Department of Psychology, Concordia University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't