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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-6-3
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pubmed:abstractText |
Serotonergic receptors were classified in the isolated human uterine artery with intact endothelium, using agonists and antagonists for 5-hydroxytryptamine (5-HT) receptors. The efficacy for different agonists rated: alpha-methyl-5-HT (5-HT2) = 5-HT (non-selective) = 2-methyl-5-HT (5-HT3) >> sumatriptan (5-HT1), and the potency as: sumatriptan = 5-HT > 5-HT > alpha-methyl-5-HT > 2-methyl-5-HT. The contractile effects of 5-HT and alpha-methyl-5-HT were antagonized by the 5-HT2 receptor antagonist ketanserin and the non-selective antagonist methiothepin. The efficacy of sumatriptan was comparatively low. No interaction was encountered between 2-methyl-5-HT and MDL72222, suggesting an absence of 5-HT3 receptors. The results indicate that the contractile serotonergic receptor population in the human uterine artery mainly comprises 5-HT2 receptors, although a minor contribution of contractile 5-HT1 receptors cannot be excluded.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0268-1161
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9070726-Dose-Response Relationship, Drug,
pubmed-meshheading:9070726-Female,
pubmed-meshheading:9070726-Humans,
pubmed-meshheading:9070726-Muscle, Smooth, Vascular,
pubmed-meshheading:9070726-Muscle Contraction,
pubmed-meshheading:9070726-Receptors, Serotonin,
pubmed-meshheading:9070726-Serotonin,
pubmed-meshheading:9070726-Uterus
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pubmed:year |
1997
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pubmed:articleTitle |
5-Hydroxytryptamine contracts human uterine artery smooth muscle predominantly via 5-HT2 receptors.
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pubmed:affiliation |
Department of Obstetrics & Gynaecology, University Hospital, Malmo, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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