rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
1997-4-15
|
pubmed:abstractText |
It has been suggested that there is a relationship between 5-fluorouracil (5-FU) dose levels and response rates. A bimonthly 2-day regimen of leucovorin (LV) and 5-FU bolus plus infusion has been found to be superior to a monthly 5-FU bolus with low dose LV. Based on these reports, a first-line Phase II study was performed in 101 patients with advanced colorectal carcinoma who were given a bimonthly combination of high dose LV and a high dose 48-hour infusion of 5-FU.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0008-543X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
79
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1100-5
|
pubmed:dateRevised |
2006-4-24
|
pubmed:meshHeading |
pubmed-meshheading:9070486-Adenocarcinoma,
pubmed-meshheading:9070486-Adult,
pubmed-meshheading:9070486-Aged,
pubmed-meshheading:9070486-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:9070486-Carcinoembryonic Antigen,
pubmed-meshheading:9070486-Colorectal Neoplasms,
pubmed-meshheading:9070486-Dose-Response Relationship, Drug,
pubmed-meshheading:9070486-Drug Administration Schedule,
pubmed-meshheading:9070486-Female,
pubmed-meshheading:9070486-Fluorouracil,
pubmed-meshheading:9070486-Humans,
pubmed-meshheading:9070486-Infusions, Intravenous,
pubmed-meshheading:9070486-Leucovorin,
pubmed-meshheading:9070486-Male,
pubmed-meshheading:9070486-Middle Aged,
pubmed-meshheading:9070486-Survival Analysis
|
pubmed:year |
1997
|
pubmed:articleTitle |
Bimonthly high dose leucovorin and 5-fluorouracil 48-hour continuous infusion in patients with advanced colorectal carcinoma. Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD).
|
pubmed:affiliation |
Hopital Saint-Antoine, Paris, France.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study,
Clinical Trial, Phase II
|