Linked Life Data

9069526

Source:http://linkedlifedata.com/resource/pubmed/id/9069526

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-6-19
pubmed:abstractText
Ubiquinol-10, the reduced form of ubiquinone-10 (coenzyme Q10), is a potent lipophilic antioxidant present in nearly all human tissues. The exceptional oxidative lability of ubiquinol-10 implies that it may represent a sensitive index of oxidative stress. The present study was undertaken to assess the hypothesis that the level of ubiquinol-10 in human plasma can discriminate between healthy subjects and patients who are expected to be subjected to an increased oxidative stress in vivo. Using a newly developed method, we measured plasma ubiquinol-10 in 38 hyperlipidaemic patients with and without further complications, such as coronary heart disease, hypertension, or liver disease, and in 30 healthy subjects. The oxidizability of plasma samples obtained from hyperlipidaemic patients was found to be increased in comparison with control subjects, suggesting that the patients were subjected to a higher oxidative stress in vivo than the controls. Plasma ubiquinol-10, expressed as a percentage of total ubiquinol-10 + ubiquinone-10 or normalized to plasma lipids, was lower in the patients than in controls (P = 0.001 and 0.008, respectively). The proportion of ubiquinol-10 decreased in the order young controls > aged controls > hyperlipidaemic patients without complications > hyperlipidaemic patients with complications (P = 0.003). A negative correlation was found between the proportion of ubiquinol-10 and plasma triglycerides. The hyperlipidaemic patients with hypertension had a lower proportion of ubiquinol-10 than subjects without. When the study population was divided into smokers and non-smokers, plasma ubiquinol-10 was found to be reduced amongst smokers, independently of whether it was expressed as a percentage of total ubiquinol-10 + ubiquinone-10 (P = 0.006) or normalized to plasma lipids (P = 0.009). These data suggest that the level of ubiquinol-10 in human plasma may represent a sensitive index of oxidative stress in vivo especially indicative of early oxidative damage. Measuring plasma ubiquinol-10 can be proposed as a practical approach to assess oxidative stress in humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9150
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-26
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9069526-Adult, pubmed-meshheading:9069526-Alcohol Drinking, pubmed-meshheading:9069526-Amidines, pubmed-meshheading:9069526-Antidotes, pubmed-meshheading:9069526-Body Mass Index, pubmed-meshheading:9069526-Coronary Disease, pubmed-meshheading:9069526-Female, pubmed-meshheading:9069526-Humans, pubmed-meshheading:9069526-Hyperlipidemias, pubmed-meshheading:9069526-Hypertension, pubmed-meshheading:9069526-Lipid Peroxidation, pubmed-meshheading:9069526-Lipoxygenase, pubmed-meshheading:9069526-Liver Diseases, pubmed-meshheading:9069526-Male, pubmed-meshheading:9069526-Middle Aged, pubmed-meshheading:9069526-Oxidation-Reduction, pubmed-meshheading:9069526-Oxidative Stress, pubmed-meshheading:9069526-Regression Analysis, pubmed-meshheading:9069526-Risk Factors, pubmed-meshheading:9069526-Smoking, pubmed-meshheading:9069526-Spectrophotometry, pubmed-meshheading:9069526-Triglycerides, pubmed-meshheading:9069526-Ubiquinone
pubmed:year
1997
pubmed:articleTitle
Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia.
pubmed:affiliation
Biochemisches Labor, Medizinische Kern- und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't