Linked Life Data

9068976

Source:http://linkedlifedata.com/resource/pubmed/id/9068976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-6-5
pubmed:abstractText
1. Patch-clamp whole cell recording was performed to elucidate whether or not ethanol, at low concentration, has an effect on the GABAA receptor in cultured rat cortical neurons as compared with flunitrazepam. 2. Bath application of ethanol (0.01%) or flunitrazepam (1 mM) potentiated the peak amplitude of GABA-induced (10 microM) current without affecting the equilibrium potential. 3. The decay time constant and time to peak of GABA-induced current were shortened in the presence of ethanol or flunitrazepam. 4. These findings indicate that a low concentration of ethanol and flunitrazepam potentiates the GABA-induced current concomitantly with acceleration of desensitization to the drug.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Potentiation by ethanol of GABA-induced current and facilitation of its desensitization in cultured rat cortical neurons.
pubmed:affiliation
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't