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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-6-5
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pubmed:abstractText |
Sera were taken over a 5 year period from Gambian children vaccinated in 1983, when aged 1-4 years, with A + C meningococcal capsular polysaccharide, ELISA tests were devised to determine the concentrations of immunoglobulin A, G and M reacting with A polysaccharide and of IgG reacting with Opc protein, IgA1 protease and an internal 104 mer peptide derived from IgA1 protease. Vaccination resulted in a brief rise of antibodies to A polysaccharide followed by decline to pre-immunization levels. IgM levels were very high even before vaccination. Antibodies to Opc protein stimulated by natural exposure also declined over the 5 year period. In contrast, antibodies stimulated by natural exposure to IgA1 protease or to the internal peptide remained constant or increased (final geometric mean level of 47 micrograms IgG ml-1). We speculate that healthy carriage of Neisseria meningitidis or Haemophilus influenzae is responsible for this increase in IgG concentration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/IgA-specific serine endopeptidase,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/meningococcal group A polysaccharide,
http://linkedlifedata.com/resource/pubmed/chemical/opc protein, bacteria
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
209-19
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9066040-Amino Acid Sequence,
pubmed-meshheading:9066040-Antibodies, Bacterial,
pubmed-meshheading:9066040-Antigens, Bacterial,
pubmed-meshheading:9066040-Antigens, Surface,
pubmed-meshheading:9066040-Bacterial Outer Membrane Proteins,
pubmed-meshheading:9066040-Bacterial Vaccines,
pubmed-meshheading:9066040-Child, Preschool,
pubmed-meshheading:9066040-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9066040-Humans,
pubmed-meshheading:9066040-Immunoglobulin G,
pubmed-meshheading:9066040-Infant,
pubmed-meshheading:9066040-Molecular Sequence Data,
pubmed-meshheading:9066040-Neisseria meningitidis,
pubmed-meshheading:9066040-Polysaccharides, Bacterial,
pubmed-meshheading:9066040-Serine Endopeptidases
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pubmed:year |
1997
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pubmed:articleTitle |
Persistence of antibodies to meningococcal IgA1 protease versus decay of antibodies to group A polysaccharide and Opc protein.
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pubmed:affiliation |
Max-Planck Institut für molekulare Genetik, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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