Linked Life Data

9065321

Source:http://linkedlifedata.com/resource/pubmed/id/9065321

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-5-29
pubmed:abstractText
The clinical usefulness of two-dimensional measurements of regional cerebral blood flow (rCBF) for diagnosis of dementia is discussed on the basis of data from 150 patients with autopsy-based diagnosis. The specificity of Alzheimer's disease is found to be very good but the sensitivity only in the order of 75-80%, the majority of the mislabelled cases having selective incomplete white matter infarcts in addition to their Alzheimer pathology. Frontal lobe dementia is recognized by rCBF with high sensitivity but fairly low specificity due to the fact that frontal flow decreases are shared with several other disorders. Regarding cerebrovascular dementia the sensitivity is rather good (95%) while specificity is somewhat lower (70-75%). It is argued that rCBF should be interpreted diagnostically only when clear-cut findings are made preferably in a series of measurements. The noninvasiveness, repeatability, low radiation dose and low cost makes the present method an excellent tool for research as well as for clinical routine use.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1420-8008
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
92-7
pubmed:dateRevised
2008-3-24
pubmed:meshHeading
pubmed:articleTitle
Regional cerebral blood flow measurements in the clinical evaluation of demented patients.
pubmed:affiliation
Department of Psychiatry, University Hospital, Lund, Sweden.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't