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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-4-9
|
| pubmed:abstractText |
The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultrastructural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0032-0943
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
81-3
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9063100-3T3 Cells,
pubmed-meshheading:9063100-Animals,
pubmed-meshheading:9063100-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9063100-Cell Death,
pubmed-meshheading:9063100-Humans,
pubmed-meshheading:9063100-Mice,
pubmed-meshheading:9063100-Microscopy, Electron,
pubmed-meshheading:9063100-Pyrones,
pubmed-meshheading:9063100-Tumor Cells, Cultured
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Cytotoxicity and electron microscopy of cell death induced by goniothalamin.
|
| pubmed:affiliation |
Department of Biotechnology, Faculty of Food Science and Biotechnology, Universiti Pertanian Malaysia, Selangor, Malaysia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|