Linked Life Data

9062662

Source:http://linkedlifedata.com/resource/pubmed/id/9062662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-7-9
pubmed:abstractText
Although the close relationship between the thymus and neuroendocrine system during the aging process has been well documented, influence of the thymus on the cognitive function of the central nervous system remains unknown. Male ddY mice were thymectomized 3-4 weeks after birth. Learning behavior, tested in a step-down test and in a spatial memory task, was significantly impaired in thymectomized mice at 10 months, but not before 5 months, after thymectomy. Reduced immune response was also not obvious before 10 months. These results suggested that thymectomy in young adult life in mice not only impaired the immune response, but also deteriorated the learning and memory ability, and that learning disorders in thymectomized mice could be utilized as a new screening model for cognitive enhancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Learning disorders in thymectomized mice: a new screening model for cognitive enhancer.
pubmed:affiliation
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
pubmed:publicationType
Journal Article