| pubmed-article:9062368 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0019351 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0019342 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0001367 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C1512656 | lld:lifeskim |
| pubmed-article:9062368 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:9062368 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9062368 | pubmed:dateCreated | 1997-4-4 | lld:pubmed |
| pubmed-article:9062368 | pubmed:abstractText | Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We performed a series of studies to evaluate the frequency and pattern of HSV-2 reactivation using both viral isolation and HSV PCR assay. Daily samples of genital secretions were obtained from 27 HSV-2 seropositive women; a subset of subjects obtained samples while receiving oral acyclovir 400 mg PO twice a day. HSV DNA was detected in genital swab specimens on 28% of 1,410 d compared with 8.1% of days by viral isolation. 11 of 20 women had HSV DNA detected on > 20% of days, 4 on > 50%, and 2 on > 75% of days; in contrast, none of the women shed on > 21% of days by viral isolation. The daily administration of oral acyclovir promptly reduced the frequency of HSV DNA detection by a median of 80%. Within 3-4 d of discontinuing daily acyclovir, HSV DNA again appeared in the genital area. HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide. | lld:pubmed |
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| pubmed-article:9062368 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9062368 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9062368 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9062368 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9062368 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9062368 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:CoreyLL | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:WaldAA | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:DavisGG | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:ConeRR | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:HobsonAA | lld:pubmed |
| pubmed-article:9062368 | pubmed:author | pubmed-author:ZehJJ | lld:pubmed |
| pubmed-article:9062368 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9062368 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9062368 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:9062368 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9062368 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9062368 | pubmed:pagination | 1092-7 | lld:pubmed |
| pubmed-article:9062368 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9062368 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9062368 | pubmed:articleTitle | Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. | lld:pubmed |
| pubmed-article:9062368 | pubmed:affiliation | Department of Medicine, University of Washington, Seattle 98195, USA. annawald@u.washington.edu | lld:pubmed |
| pubmed-article:9062368 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9062368 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9062368 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9062368 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
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