|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1997-4-4
|
|
pubmed:abstractText |
Reactivation of herpes simplex virus type 2 (HSV-2) occurs intermittently as perceived clinically and by viral culture. We performed a series of studies to evaluate the frequency and pattern of HSV-2 reactivation using both viral isolation and HSV PCR assay. Daily samples of genital secretions were obtained from 27 HSV-2 seropositive women; a subset of subjects obtained samples while receiving oral acyclovir 400 mg PO twice a day. HSV DNA was detected in genital swab specimens on 28% of 1,410 d compared with 8.1% of days by viral isolation. 11 of 20 women had HSV DNA detected on > 20% of days, 4 on > 50%, and 2 on > 75% of days; in contrast, none of the women shed on > 21% of days by viral isolation. The daily administration of oral acyclovir promptly reduced the frequency of HSV DNA detection by a median of 80%. Within 3-4 d of discontinuing daily acyclovir, HSV DNA again appeared in the genital area. HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1309846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1310837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1315326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1333488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1499348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1654360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1851732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-1894930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-209847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2152951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2543928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2831380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2835389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2839575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-2846647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-3005859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-3034759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-3404600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-4371760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-6245170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-6250402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-6261108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-6344712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-7503497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-7643884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-7706811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-7940755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-7978697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-8078144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9062368-8394375
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
99
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1092-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:9062368-Acyclovir,
pubmed-meshheading:9062368-Administration, Oral,
pubmed-meshheading:9062368-Adult,
pubmed-meshheading:9062368-Antibodies, Viral,
pubmed-meshheading:9062368-Antiviral Agents,
pubmed-meshheading:9062368-Blotting, Western,
pubmed-meshheading:9062368-Cross-Over Studies,
pubmed-meshheading:9062368-DNA, Viral,
pubmed-meshheading:9062368-Double-Blind Method,
pubmed-meshheading:9062368-Female,
pubmed-meshheading:9062368-Genitalia, Female,
pubmed-meshheading:9062368-Herpes Genitalis,
pubmed-meshheading:9062368-Herpesvirus 2, Human,
pubmed-meshheading:9062368-Humans,
pubmed-meshheading:9062368-Immunocompetence,
pubmed-meshheading:9062368-Pilot Projects,
pubmed-meshheading:9062368-Polymerase Chain Reaction,
pubmed-meshheading:9062368-Recurrence,
pubmed-meshheading:9062368-Serologic Tests,
pubmed-meshheading:9062368-Sexually Transmitted Diseases,
pubmed-meshheading:9062368-Time Factors,
pubmed-meshheading:9062368-Virus Latency,
pubmed-meshheading:9062368-Virus Shedding
|
|
pubmed:year |
1997
|
|
pubmed:articleTitle |
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.
|
|
pubmed:affiliation |
Department of Medicine, University of Washington, Seattle 98195, USA. annawald@u.washington.edu
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial
|
