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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1997-5-13
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|
pubmed:abstractText |
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct impact of 7,8-dihydroneopterin on tumor necrosis factor alpha-mediated programmed cell death. We report here that 7,8-dihydroneopterin and hydrogen peroxide upregulate the production of interferon-gamma, thereby establishing an autocrine feed-back loop. Data put emphasis on the role of neopterin-derivates within the cytokine network.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0171-2985
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
196
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
350-5
|
|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:9061375-Antioxidants,
pubmed-meshheading:9061375-Free Radicals,
pubmed-meshheading:9061375-Gene Expression Regulation,
pubmed-meshheading:9061375-Humans,
pubmed-meshheading:9061375-Interferon-gamma,
pubmed-meshheading:9061375-Jurkat Cells,
pubmed-meshheading:9061375-Neopterin,
pubmed-meshheading:9061375-Promoter Regions, Genetic,
pubmed-meshheading:9061375-Pteridines,
pubmed-meshheading:9061375-Superoxides,
pubmed-meshheading:9061375-T-Lymphocytes,
pubmed-meshheading:9061375-Up-Regulation
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
7,8-Dihydroneopterin upregulates interferon-gamma promoter in T cells.
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|
pubmed:affiliation |
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
