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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-4-7
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pubmed:abstractText |
We have studied the effects of LP-BM5 MuLV-induced murine acquired immunodeficiency syndrome (MAIDS) on concomitant murine cytomegalovirus (MCMV) infection in the livers of C57BL mice. A delayed inflammatory response in livers of mice with MAIDS (M+) on day 4 was associated with impaired clearance of MCMV-infected cells 6 days after infection. This correlated with increased levels of inflammation and serum alanine transaminase. The latter reflects enhanced hepatic necrosis, which was evident histologically. Delayed-type hypersensitivity responses to MCMV antigen were unimpaired in M+ mice and were mediated by CD8+ cells. Depletion of NK1.1+ cells from M+ mice increased MCMV replication and associated liver damage on day 6, whereas CD8+ depletion had little effect. In contrast, in the presence of CD8+ cells M- C57BL mice did not require NK1.1+ cells for control of hepatic MCMV infection, but dual NK1.1+ and CD8+ depletion dramatically potentiated hepatic MCMV replication. Our results suggest that M+ mice may acquire non-NK1.1+ and non-CD8+ cells that are able to partially control hepatic MCMV infection. These findings are discussed with reference to mortality in M+ mice after high-dose MCMV infection, as this is initially delayed but ultimately higher than in M- controls.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1378069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1503680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1558086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1653590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1659595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-1974851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2065888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-207997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-208441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2154543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2159050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2160500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2165035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2169300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-231945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2352539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2412279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2544664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2545779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2564415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2821177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2839916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2841381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-2984305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-3003382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-3006642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-3036059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-3489805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-3871115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-4362997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6087073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6179875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6207307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6247279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6257788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6260682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6272291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6287845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6288849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6309965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6311021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6329356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-6331345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-7552475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-7994901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-8380608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-8699122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-8887497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060844-8889445
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1089-100
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9060844-Animals,
pubmed-meshheading:9060844-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9060844-Cell Count,
pubmed-meshheading:9060844-Female,
pubmed-meshheading:9060844-Hepatitis, Viral, Animal,
pubmed-meshheading:9060844-Herpesviridae Infections,
pubmed-meshheading:9060844-Hypersensitivity, Delayed,
pubmed-meshheading:9060844-Killer Cells, Natural,
pubmed-meshheading:9060844-Liver,
pubmed-meshheading:9060844-Mice,
pubmed-meshheading:9060844-Mice, Inbred C57BL,
pubmed-meshheading:9060844-Murine Acquired Immunodeficiency Syndrome,
pubmed-meshheading:9060844-Muromegalovirus,
pubmed-meshheading:9060844-Specific Pathogen-Free Organisms,
pubmed-meshheading:9060844-Survival Rate,
pubmed-meshheading:9060844-Virus Replication
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pubmed:year |
1997
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pubmed:articleTitle |
Effect of a retroviral immunodeficiency syndrome on murine cytomegalovirus-induced hepatitis.
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pubmed:affiliation |
Department of Microbiology, University of Western Australia, Nedlands, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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