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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-4-7
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pubmed:abstractText |
Dysplastic colon adenomas are thought to arise from growth of clones of APC -/- colonic epithelial cells. Isolated clusters of dysplastic crypts are often observed in patients with familial adenomatous polyposis. These patients have genotype APC +/-, and the clusters of dysplastic crypts (called microadenoma or aberrant crypt foci) are thought to represent an early stage in the expansion of a mutant clone of APC -/- cells. It is thought that the growth of these clusters of mutant crypts results from crypt replication through a process similar to what occurs in the normal crypt cycle. We measured the relative replication rate of mutant crypts by analyzing the size of clusters of mutant crypts in APC +/- individuals and found that mutant APC -/- crypts replicate more rapidly than do normal APC +/- (i.e., nonneoplastic) crypts. In contrast, the replication rate of mutant crypts in Apc +/- mice is not significantly different from that of normal crypts, thus supporting previous findings that aberrant crypt foci do not contribute significantly to the colon adenoma population in adult Apc +/- mice. Intriguingly, we found an effect of Apc heterozygosity on the frequency of branching crypts in young mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-1350108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-1651563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-1678319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-1706308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-1913650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-3094402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-3663832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-3719076,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-3993991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-6689675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-7270915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-7590437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-7761481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-7923189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-7923190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-8072296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-8553013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-8674041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9060821-8733477
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
150
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9060821-Adenomatous Polyposis Coli,
pubmed-meshheading:9060821-Aging,
pubmed-meshheading:9060821-Animals,
pubmed-meshheading:9060821-Colon,
pubmed-meshheading:9060821-Colonic Diseases,
pubmed-meshheading:9060821-Colonic Neoplasms,
pubmed-meshheading:9060821-Female,
pubmed-meshheading:9060821-Genes, APC,
pubmed-meshheading:9060821-Humans,
pubmed-meshheading:9060821-Jejunum,
pubmed-meshheading:9060821-Male,
pubmed-meshheading:9060821-Mice,
pubmed-meshheading:9060821-Mice, Inbred C57BL,
pubmed-meshheading:9060821-Mutation,
pubmed-meshheading:9060821-Precancerous Conditions,
pubmed-meshheading:9060821-Species Specificity
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pubmed:year |
1997
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pubmed:articleTitle |
APC mutation and the crypt cycle in murine and human intestine.
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pubmed:affiliation |
Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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