Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2-3
|
| pubmed:dateCreated |
1997-7-14
|
| pubmed:abstractText |
M7 (5,6-dihydroxy-2-dimethylaminotetralin) produces in anesthetized rats a hypotensive response previously attributed to peripheral dopaminergic mechanisms. We re-examined the effects of this drug on arterial blood pressure, heart rate and sympathetic nerve activity in anesthetized rats and dogs. M7 (1-100 micrograms/kg i.v.) produced in the rats transient dose-dependent pressor effects, with bradycardia and sympatho-inhibition, followed by long-lasting dose-dependent hypotension, bradycardia and sympatho-inhibition. The sympatho-inhibitory and hypotensive effects were comparable in baroreceptor-denervated rats and were reversed by idazoxan (0.1 mg/kg i.v.). The sympatho-inhibitory response induced by M7 (1-100 micrograms/kg) was prevented by treatment with the specific alpha 2-adrenoceptor antagonist, 2-methoxy-idazoxan (0.03 mg/kg i.v.). This central effect of M7 was not altered by treatment with the alpha 1-adrenoceptor antagonist, prazosin (0.1 mg/kg i.v.), and was reduced by treatment with the alpha 2-adrenoceptor antagonists, yohimbine (1 mg/kg i.v.) or idazoxan (0.3 mg/kg i.v.), and the dopaminergic antagonists, haloperidol (0.5 mg/kg i.v.) or sulpiride (3 mg/kg i.v.). Bilateral microinjections of M7 (0.3-3 nmol) into the rostroventral medulla in the rat produced dose-dependent hypotension, bradycardia and sympathetic nerve inhibition which were reversed and prevented by bilateral microinjection of 2-methoxy-idazoxan (1 nmol) into the same sites. Microinjections of 2-methoxy-idazoxan into the rostroventral medulla also inhibited the central effects of M7 at 0.03 mg/kg i.v. In anesthetized dogs, M7 administered into the cisterna magna (1-10 micrograms/kg) reduced arterial blood pressure, heart rate and sympathetic nerve activity; these effects were reversed by administration of 2-methoxy-idazoxan (0.03 mg/kg i.v.). In conclusion, M7, a rigid catecholamine, produces a potent central sympatho-inhibitory and hypotensive effect by activation of alpha 2-adrenoceptors.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-methoxyidazoxan,
http://linkedlifedata.com/resource/pubmed/chemical/5,6-dihydroxy-2-dimethylaminotetrali...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Emetics,
http://linkedlifedata.com/resource/pubmed/chemical/Idazoxan,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthols,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
320
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
151-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9059848-Adrenergic alpha-Antagonists,
pubmed-meshheading:9059848-Anesthesia,
pubmed-meshheading:9059848-Animals,
pubmed-meshheading:9059848-Blood Pressure,
pubmed-meshheading:9059848-Central Nervous System,
pubmed-meshheading:9059848-Cisterna Magna,
pubmed-meshheading:9059848-Dogs,
pubmed-meshheading:9059848-Dopamine Antagonists,
pubmed-meshheading:9059848-Dose-Response Relationship, Drug,
pubmed-meshheading:9059848-Emetics,
pubmed-meshheading:9059848-Female,
pubmed-meshheading:9059848-Heart Rate,
pubmed-meshheading:9059848-Idazoxan,
pubmed-meshheading:9059848-Male,
pubmed-meshheading:9059848-Microinjections,
pubmed-meshheading:9059848-Naphthols,
pubmed-meshheading:9059848-Pressoreceptors,
pubmed-meshheading:9059848-Rats,
pubmed-meshheading:9059848-Rats, Sprague-Dawley,
pubmed-meshheading:9059848-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:9059848-Splanchnic Nerves,
pubmed-meshheading:9059848-Sympathetic Nervous System,
pubmed-meshheading:9059848-Vagotomy
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
The central sympatho-inhibitory effect of 5,6-dihydroxy-2-dimethylaminotetralin (M7) is mediated by alpha 2-adrenoceptors.
|
| pubmed:affiliation |
Division of Angiology, Servier Research Institute, Suresnes, France.
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| pubmed:publicationType |
Journal Article
|