9055092

Source:http://linkedlifedata.com/resource/pubmed/id/9055092

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0032659, umls-concept:C0034865, umls-concept:C1521828
pubmed:issue	3
pubmed:dateCreated	1997-5-29
pubmed:abstractText	Population genetic models often use a population recombination parameter 4Nc, where N is the effective population size and c is the recombination rate per generation. In many ways 4Nc is comparable to 4Nu, the population mutation rate. Both combine genome level and population level processes, and together they describe the rate of production of genetic variation in a population. However, 4Nc is more difficult to estimate. For a population sample of DNA sequences, historical recombination can only be detected if polymorphisms exist, and even then most recombination events are not detectable. This paper describes an estimator of 4Nc, hereafter designated gamma (gamma), that was developed using a coalescent model for a sample of four DNA sequences with recombination. The reliability of gamma was assessed using multiple coalescent simulations. In general gamma has low to moderate bias, and the reliability of gamma is comparable, though less, than that for a widely used estimator of 4Nu. If there exists an independent estimate of the recombination rate (per generation, per base pair), gamma can be used to estimate the effective population size or the neutral mutation rate.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/GM-17745-01
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-1145509, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-1840702, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-2024230, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-2513255, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-2599369, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-3110004, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-3443297, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-3870876, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-4029609, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-5364968, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-6612631, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-6628982, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-7498781, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-7705636, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-7907422, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-7982556, http://linkedlifedata.com/resource/pubmed/commentcorrection/9055092-8601488
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374636
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0016-6731
pubmed:author	pubmed-author:HerCC, pubmed-author:WakeleyJJ
pubmed:issnType	Print
pubmed:volume	145
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	833-46
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:9055092-Genetics, Population, pubmed-meshheading:9055092-Recombination, Genetic
pubmed:year	1997
pubmed:articleTitle	A coalescent estimator of the population recombination rate.
pubmed:affiliation	Department of Ecology, Evolution and Natural Resources, Nelson Laboratories, Rutgers University, Piscataway, New Jersey 08855-1059, USA. hey@mbcl.rutgers.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.