Linked Life Data

9053794

Source:http://linkedlifedata.com/resource/pubmed/id/9053794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-3-13
pubmed:abstractText
The reticular thalamic nucleus consists of densely packed neurons containing the neurotransmitter GABA. It surrounds the lateral border of the thalamus, has extensive reciprocal connections with thalamocortical neurons, and is thought to be involved in attentional processes. The reticular thalamic nucleus also receives direct and indirect inputs from the basal ganglia, suggesting that it may be involved in relaying motor information to the thalamus and cortex. We examined the possibility that decreased dopaminergic transmission in the basal ganglia indirectly affects the reticular thalamic nucleus. Rats received unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta and were killed two or three weeks after the lesion. Sections of the reticular thalamic nucleus were processed for in situ hybridization histochemistry at the single cell level with RNA probes for both isoforms of glutamate decarboxylase (M(r) 65,000: glutamate decarboxylase 65 and M(r) 67,000: glutamate decarboxylase 67), the rate limiting enzyme of GABA synthesis. Unilateral nigrostriatal dopaminergic lesions induced a topographically specific, bilateral increase in glutamate decarboxylase 67 messenger RNA in neurons of the lateral and ventral reticular thalamic nucleus. A much smaller increase in glutamate decarboxylase 65 messenger RNA was observed which was significant only ipsilateral to the lesion. Short- (seven day) and long-term (eight month) treatments with the antipsychotic drug haloperidol, in regimens that preferentially block D2 dopamine receptors, induced catalepsy and orofacial dyskinesia, respectively, but did not alter glutamate decarboxylase 67 messenger RNA levels in the reticular thalamic nucleus. Thus, loss of dopaminergic terminals, but not blockade of D2 dopamine receptors, induced the effects observed in the reticular thalamic nucleus. The results reveal a novel bilateral effect of unilateral dopamine depletion. In view of the role of the reticular thalamic nucleus in tremor and attentional processes, which are altered in Parkinson's disease, this effect may contribute to the clinical manifestations of nigrostriatal dopamine depletion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-95
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:9053794-Animals, pubmed-meshheading:9053794-Dopamine, pubmed-meshheading:9053794-Dopamine Antagonists, pubmed-meshheading:9053794-Gene Expression Regulation, Enzymologic, pubmed-meshheading:9053794-Glutamate Decarboxylase, pubmed-meshheading:9053794-Haloperidol, pubmed-meshheading:9053794-In Situ Hybridization, pubmed-meshheading:9053794-Male, pubmed-meshheading:9053794-Neostriatum, pubmed-meshheading:9053794-Oxidopamine, pubmed-meshheading:9053794-Parasympatholytics, pubmed-meshheading:9053794-RNA, Messenger, pubmed-meshheading:9053794-Rats, pubmed-meshheading:9053794-Rats, Sprague-Dawley, pubmed-meshheading:9053794-Scopolamine Hydrobromide, pubmed-meshheading:9053794-Substantia Nigra, pubmed-meshheading:9053794-Sympatholytics, pubmed-meshheading:9053794-Thalamic Nuclei
pubmed:year
1996
pubmed:articleTitle
Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus.
pubmed:affiliation
Department of Pharmacology, University of Pennsylvania, Philadelphia 19104, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.