Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-3-13
pubmed:abstractText
Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon gamma trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, probably secreted by antigen-presenting cells, is able to polarize naive CD4+ T cells to effector Th2 cells by inducing the initial production of IL-4 in CD4+ T cells. These results show that the nature of the cytokine (IL-12 or IL-6), which is produced by antigen-presenting cells in response to a particular pathogen, is a key factor in determining the nature of the immune response.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1357073, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1411569, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1438305, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1533441, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1542794, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1636090, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1701020, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1826367, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1840554, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-1940369, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2112087, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2117636, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2147202, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2171780, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2188664, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2253878, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2261637, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2571940, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2574680, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-2788034, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-3136546, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-3500054, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7532678, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7534215, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7594540, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7595230, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7699337, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7749982, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7768607, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7901851, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7902780, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7904900, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-7908323, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8096850, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8097322, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8097338, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8102388, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8127368, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8131749, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8284217, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8336717, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8360477, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8384717, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8409467, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8415766, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8428966, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8441422, http://linkedlifedata.com/resource/pubmed/commentcorrection/9053446-8496684
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells.
pubmed:affiliation
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8011, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't