Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-3-31
|
| pubmed:abstractText |
Two novel natural products, lanneaquinol (1) and 2'(R)-hydroxylanneaquinol (2), were isolated from the organic extract of the plant Lannea welwitschii (Hiern) Engl. Their structures were solved by spectroanalytical methods and confirmed by comparison to synthetic models. The absolute configuration of 2 was determined by the modified Mosher method. Both compounds exhibited modest cytotoxicity against the NCI panel of 60 human tumor cell lines. The structures of two isomeric 4,5-dihydroxy-5-alkyl-2-cyclohexenones (7 and 8), which appear to be biogenetic precursors of 1 and 2, were also elucidated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
116-21
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9051911-Alkylation,
pubmed-meshheading:9051911-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:9051911-Chromatography, Ion Exchange,
pubmed-meshheading:9051911-Humans,
pubmed-meshheading:9051911-Hydroquinones,
pubmed-meshheading:9051911-Magnetic Resonance Spectroscopy,
pubmed-meshheading:9051911-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:9051911-Stereoisomerism,
pubmed-meshheading:9051911-Tumor Cells, Cultured
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Novel cytotoxic, alkylated hydroquinones from Lannea welwitschii.
|
| pubmed:affiliation |
Laboratory of Drug Discovery Research and Development, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
|
| pubmed:publicationType |
Journal Article
|