Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-20
pubmed:abstractText
A combination of transient expression of wild-type and a mutant muscle nicotinic receptor (AChR) found in a patient suffering from a congenital myasthenic syndrome and single-channel recordings was used to characterize the action of ephedrine on the AChR. In the presence of ephedrine, both types of AChR channel showed a flickering behaviour and a dose-dependent reduction in the mean open time. The duration of the blocking events was dependent on the membrane potential. The forward rate constant for the blocking process was of the order of 10(7) M-1 s-1 in both types of AChR. The results are consistent with ephedrine acting as a channel blocker in wild-type AChR as well as in long-lived AChR channels present in patients with the slow-channel syndrome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-21
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Ephedrine blocks wild-type and long-lived mutant acetylcholine receptor channels.
pubmed:affiliation
Instituto de Investigaciones Bioquímicas de Bahía Blanca, Argentina.
pubmed:publicationType
Journal Article