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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1997-5-20
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pubmed:abstractText |
Interleukin-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-noceiceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (delta opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the delta opioid receptor is functional.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9051743-Analgesics,
pubmed-meshheading:9051743-Animals,
pubmed-meshheading:9051743-Binding, Competitive,
pubmed-meshheading:9051743-Cats,
pubmed-meshheading:9051743-Cell Line,
pubmed-meshheading:9051743-Cyclic AMP,
pubmed-meshheading:9051743-Diprenorphine,
pubmed-meshheading:9051743-Humans,
pubmed-meshheading:9051743-Interleukin-2,
pubmed-meshheading:9051743-Male,
pubmed-meshheading:9051743-Narcotic Antagonists,
pubmed-meshheading:9051743-Neural Pathways,
pubmed-meshheading:9051743-Peripheral Nervous System,
pubmed-meshheading:9051743-Rats,
pubmed-meshheading:9051743-Rats, Wistar,
pubmed-meshheading:9051743-Receptors, Opioid,
pubmed-meshheading:9051743-Receptors, Opioid, delta,
pubmed-meshheading:9051743-Signal Transduction,
pubmed-meshheading:9051743-Transfection
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pubmed:year |
1996
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pubmed:articleTitle |
Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction.
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pubmed:affiliation |
Shanghai Institutes of Biochemistry, China.
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pubmed:publicationType |
Journal Article
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