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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1997-5-15
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pubmed:abstractText |
We investigated the influence of the vascular and renal thromboxane system on the antihypertensive effects of the alpha 1 adrenoceptor antagonist (alpha 1 blocker) bunazosin in spontaneously hypertensive rats (SHR). SHR were treated for 2 weeks with the alpha 1, blocker bunazosin (0.5 mg/kg body weight/day). The systolic blood pressure immediately declined with bunazosin treatment, and then rose toward the level observed in untreated SHR. This antihypertensive effect was accompanied by a decrease in the ratio of prostacyclin to thromboxane A2 in the vascular wall and the kidney. A subdepressor dose of the thromboxane synthase inhibitor OKY-046 lessened the thromboxane generation during bunazosin treatment, and synergistically potentiated the antihypertensive action of the alpha 1 blocker. Such synergy was also observed between OKY-046 and prazosin, an alternative alpha 1 blocker, but not with amosulalol, an alpha 1 blocker having no quinazoline moiety. alpha 1 blockers with a quinazoline moiety dose-dependently stimulate thromboxane generation in cultured smooth muscle cells from SHR. These data indicate that alpha 1 blockers enhance thromboxane generation in the arterial wall and kidney, thereby contributing to the lessening of the antihypertensive effects observed during alpha 1 blocker treatment.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosanoids,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Methacrylates,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane-A Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxanes,
http://linkedlifedata.com/resource/pubmed/chemical/amosulalol,
http://linkedlifedata.com/resource/pubmed/chemical/bunazosin,
http://linkedlifedata.com/resource/pubmed/chemical/ozagrel
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0952-3278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9051722-Adrenergic alpha-Antagonists,
pubmed-meshheading:9051722-Animals,
pubmed-meshheading:9051722-Antihypertensive Agents,
pubmed-meshheading:9051722-Aorta,
pubmed-meshheading:9051722-Blood Pressure,
pubmed-meshheading:9051722-Body Weight,
pubmed-meshheading:9051722-Cells, Cultured,
pubmed-meshheading:9051722-Drug Synergism,
pubmed-meshheading:9051722-Eicosanoids,
pubmed-meshheading:9051722-Ethanolamines,
pubmed-meshheading:9051722-Kidney,
pubmed-meshheading:9051722-Methacrylates,
pubmed-meshheading:9051722-Muscle, Smooth, Vascular,
pubmed-meshheading:9051722-Prazosin,
pubmed-meshheading:9051722-Quinazolines,
pubmed-meshheading:9051722-Rats,
pubmed-meshheading:9051722-Rats, Inbred SHR,
pubmed-meshheading:9051722-Sodium,
pubmed-meshheading:9051722-Thromboxane-A Synthase,
pubmed-meshheading:9051722-Thromboxanes
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pubmed:year |
1997
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pubmed:articleTitle |
Thromboxane inhibition potentiates antihypertensive effects of alpha 1 adrenoceptor antagonists in the rat.
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pubmed:affiliation |
Department of Medicine, Dokkyo University School of Medicine, Mibu, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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