Linked Life Data

9051626

Source:http://linkedlifedata.com/resource/pubmed/id/9051626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-6-5
pubmed:abstractText
Bombesin (gastrin-releasing peptide 14-27) inhibits gastric function and feeding when microinjected into the nucleus of the solitary tract (NTS)/dorsal motor nucleus of the vagus (DMV) complex. We performed a preembedding immunoelectron microscopic study in rats to describe the bombesin containing nerve terminals and to characterize their postsynaptic structures. 228 bombesin-L1 nerve terminals which made synaptic contacts in the NTS/DMV complex were studied. Labeling was heaviest over dense core vesicles and lighter over small clear vesicles. The dense core vesicles were typically located along the plasmalemma away from the synaptic face, a finding that is typical of neuropeptide containing nerve terminals. The postsynaptic structures were most often medium sized dendrites (56%) and small sized dendrites (27%), with similar percentages in the NTS and DMV. In the DMV, synapses on cell bodies (8%) were more frequent than in the NTS (1%). In the NTS, synapses on dendritic spines (10%) were more frequent than in the DMV (4%). Only a single axo-axonal contact was identified. These findings add to the increasing body of evidence that bombesin is a neurotransmitter/neuromodulator in the NTS/DMV complex. Bombesin rarely makes presynaptic (axo-axonal) contacts that might inhibit the release of excitatory neurotransmitters, but rather makes postsynaptic contacts potentially effecting vagal motoneurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-1838
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
174-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Ultrastructure of bombesin-like immunoreactive nerve terminals in the nucleus of the solitary tract and the dorsal motor nucleus.
pubmed:affiliation
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. lynnl@jeflin.tju.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.