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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1997-4-1
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pubmed:databankReference | |
pubmed:abstractText |
More than 3 kb of the human (h)IGFBP-4 gene 5'-flanking region was sequenced and assessed for promoter activity. The hIGFBP-4 promoter resides within a CpG island and demonstrates strong basal activity in human osteoblast-like osteosarcoma and COS-7 monkey kidney cells. Transient transfection of cells with hIGFBP-4 promoter-linked deletion constructs demonstrated that multiple cooperating cis-acting elements within 836 bp of the 5'-flanking region contributed to overall promoter strength.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
1350
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
136-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9048882-Animals,
pubmed-meshheading:9048882-Base Sequence,
pubmed-meshheading:9048882-COS Cells,
pubmed-meshheading:9048882-Cell Line,
pubmed-meshheading:9048882-CpG Islands,
pubmed-meshheading:9048882-DNA,
pubmed-meshheading:9048882-Humans,
pubmed-meshheading:9048882-Insulin-Like Growth Factor Binding Protein 4,
pubmed-meshheading:9048882-Molecular Sequence Data,
pubmed-meshheading:9048882-Oligonucleotides, Antisense,
pubmed-meshheading:9048882-Osteoblasts,
pubmed-meshheading:9048882-Plasmids,
pubmed-meshheading:9048882-Promoter Regions, Genetic,
pubmed-meshheading:9048882-Transfection
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pubmed:year |
1997
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pubmed:articleTitle |
Structural and functional analysis of the 5'-flanking region of the human insulin-like growth factor binding protein (IGFBP)-4 gene.
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pubmed:affiliation |
J.L. Pettis Memorial Veterans' Medical Center, Department of Medicine, Loma Linda University, CA 92357, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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