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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-8-28
|
| pubmed:abstractText |
The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide, small organic inhibitors of the ras nucleotide exchange process. These inhibitors bind to the ras protein in a previously unidentified binding pocket, without displacing bound nucleotide. This report also describes the development and use of mass spectrometry, NMR spectroscopy and molecular modeling techniques to elucidate the structure of a drug-protein complex, and aid in designing new ras inhibitor targets.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0968-0896
|
| pubmed:author |
pubmed-author:BauerB BBB,
pubmed-author:BrownJ EJE,
pubmed-author:CaroAA,
pubmed-author:CatinoJJ,
pubmed-author:CesarzDD,
pubmed-author:DollR JRJ,
pubmed-author:EvansC ACA,
pubmed-author:GirijavallabhanVV,
pubmed-author:HeimarkLL,
pubmed-author:HuangE CEC,
pubmed-author:JamesLL,
pubmed-author:KirschmeierPP,
pubmed-author:LiberlesSS,
pubmed-author:NashCC,
pubmed-author:PerkinsLL,
pubmed-author:PramanikB NBN,
pubmed-author:RemiszewskiS WSW,
pubmed-author:SeniorM MMM,
pubmed-author:SnowM EME,
pubmed-author:TaverasA GAG,
pubmed-author:TsarbopoulosAA,
pubmed-author:VibulbhanBB,
pubmed-author:WangY SYS,
pubmed-author:WebberS ESE,
pubmed-author:del RosarioJ DJD
|
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
125-33
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading | |
| pubmed:year |
1997
|
| pubmed:articleTitle |
Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex.
|
| pubmed:affiliation |
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
|
| pubmed:publicationType |
Journal Article
|