Linked Life Data

9043647

Source:http://linkedlifedata.com/resource/pubmed/id/9043647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-6-13
pubmed:abstractText
A correlation was found between mitochondrial matrix free magnesium ([Mg2+]m), measured by means of the fluorescent indicator Mag-Fura-2, and citrulline synthesis in rat liver mitochondria. The variation of [Mg2+]m from 0.05 to 1.7 mM by changes in external Mg2+, induced a 20 +/- 8.5% increase in the rate of citrulline synthesis, whereas a further increase of [Mg2+]m to 3.3 mM induced a return to basal values. The increase in [Mg2+]m, as well as the diminution of external pH, also promoted an elevation of matrix free Ca2+ ([Ca2+]m). An increase in [Ca2+]m, at constant [Mg2+]m and pH, resulted in a 3-fold stimulation of citrulline synthesis. The data suggest that [Mg2+]m may modulate the rate of citrulline synthesis through a direct interaction with carbamoyl-phosphate synthase I (ammonia) and, indirectly, by changing the levels of matrix Ca2+.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
179-87
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Effect of intramitochondrial Mg2+ on citrulline synthesis in rat liver mitochondria.
pubmed:affiliation
Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, México.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't