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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1997-3-11
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pubmed:abstractText |
Androgen insensitivity syndromes (AIS) in subjects with 46, XY karyotype and normal or even elevated androgen blood levels are characterized by various aberrations in male differentiation and virilization. AIS is often accompanied by a broad spectrum of abnormal binding characteristics of the androgen receptor (AR). In order to investigate the correlation between the degree of virilization defect and the type of androgen binding abnormalities and/or the nature of the mutation in the AR gene, we determined androgen binding characteristics of the AR protein and the sequence of the AR gene in clinically and biochemically well characterized patients with various degrees of androgen resistance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0300-0664
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9039340-Adolescent,
pubmed-meshheading:9039340-Androgens,
pubmed-meshheading:9039340-Child,
pubmed-meshheading:9039340-Child, Preschool,
pubmed-meshheading:9039340-Disorders of Sex Development,
pubmed-meshheading:9039340-Female,
pubmed-meshheading:9039340-Fibroblasts,
pubmed-meshheading:9039340-Humans,
pubmed-meshheading:9039340-Infant,
pubmed-meshheading:9039340-Male,
pubmed-meshheading:9039340-Point Mutation,
pubmed-meshheading:9039340-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:9039340-Protein Binding,
pubmed-meshheading:9039340-Receptors, Androgen,
pubmed-meshheading:9039340-Sequence Analysis, DNA,
pubmed-meshheading:9039340-Skin,
pubmed-meshheading:9039340-Transcriptional Activation
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pubmed:year |
1996
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pubmed:articleTitle |
Clinical and biochemical investigations and molecular analysis of subjects with mutations in the androgen receptor gene.
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pubmed:affiliation |
Department of Endocrinology and Developmental Biology, Heinrich Heine University of Düsseldorf.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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