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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1997-3-11
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pubmed:databankReference | |
pubmed:abstractText |
Ca2+ channel beta subunits regulate voltage-dependent calcium currents through direct interaction with alpha 1 subunits. The beta- and alpha 1-binding motifs are conserved, and all beta subunits can stimulate current amplitude, voltage dependence, and kinetics when coexpressed with various alpha 1 subunits. We used a positional candidate approach to determine that the ataxia and seizures in the lethargic (lh) mouse arise from mutation of the beta-subunit gene Cchb4 on mouse chromosome 2. A four-nucleotide insertion into a splice donor site results in exon skipping, translational frameshift, and protein truncation with loss of the alpha 1-binding site. The lethargic phenotype is the first example of a mammalian neurological disease caused by an inherited defect in a non-pore-forming subunit of a voltage-gated ion channel.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-92
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9039265-Amino Acid Sequence,
pubmed-meshheading:9039265-Animals,
pubmed-meshheading:9039265-Ataxia,
pubmed-meshheading:9039265-Base Sequence,
pubmed-meshheading:9039265-Brain,
pubmed-meshheading:9039265-Calcium Channels,
pubmed-meshheading:9039265-DNA Transposable Elements,
pubmed-meshheading:9039265-Exons,
pubmed-meshheading:9039265-Humans,
pubmed-meshheading:9039265-Mice,
pubmed-meshheading:9039265-Mice, Inbred BALB C,
pubmed-meshheading:9039265-Mice, Mutant Strains,
pubmed-meshheading:9039265-Molecular Sequence Data,
pubmed-meshheading:9039265-Mutation,
pubmed-meshheading:9039265-Organ Specificity,
pubmed-meshheading:9039265-RNA, Messenger,
pubmed-meshheading:9039265-RNA Splicing,
pubmed-meshheading:9039265-Seizures
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pubmed:year |
1997
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pubmed:articleTitle |
Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.
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pubmed:affiliation |
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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