Linked Life Data

9038238

Source:http://linkedlifedata.com/resource/pubmed/id/9038238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-5-28
pubmed:abstractText
This study assessed the in vivo relationship between apoptosis induced by the tumor initiator N-methyl-N-nitrosourea (MNU) and action of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse hair follicle matrix cells. Mouse hair follicles were stimulated to grow hair synchronously by plucking resting hairs and MNU was applied to the plucked skin as the apoptosis inducer. The effects of TPA on MNU-induced apoptosis, when given at different intervals before or after MNU treatment, were examined. Changes in the percentage of apoptotic cells among total hair matrix cells after TPA treatment were measured. A significant suppression in levels of MNU-induced apoptosis was observed in the animals receiving TPA 1 to 6 hr following the induction. Administration of TPA before MNU caused a reduction in numbers of apoptotic cells over the control groups, but the differences were not significant. Determination of the diurnal variation in apoptotic levels in vehicle-treated mouse hair follicles revealed a relatively constant baseline pattern, suggesting that the above apoptotic responses to MNU and TPA were not affected by the background levels of apoptosis. The findings provided in vivo evidence which would support the hypothesis that TPA promotes tumorigenesis by preventing carcinogen-initiated cells from undergoing apoptotic death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0272-0590
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
The in vivo effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on N-methyl-N-nitrosourea-induced apoptosis in mouse hair follicles.
pubmed:affiliation
Department of Biomedical Sciences, University of Guelph, Guelph, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't