Linked Life Data

9037695

Source:http://linkedlifedata.com/resource/pubmed/id/9037695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-12
pubmed:abstractText
The hox genes specify regional differences along the anterior-posterior (A/P) axis of the vertebrate embryo. This function appears to reflect an ancestral role of the hox gene complex and is conserved across phyla. During the evolution of vertebrates, this gene complex has been recruited to perform other functions as well, many of which occur later in development. Although mutational analysis in the mouse is well-suited to the study of their early function, that same function limits the utility of mutational analysis in the investigation of later functions. The use of retroviral vectors to alter gene expression in the chick embryo has emerged as an effective way to address these later functions. This paper reviews that approach and its application to the study of the hox genes in the formation of the vertebrate limb.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0032-5791
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
96-104
pubmed:dateRevised
2006-4-21
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Hox genes and embryonic development.
pubmed:affiliation
Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, USA.
pubmed:publicationType
Journal Article, Review