Linked Life Data

9037451

Source:http://linkedlifedata.com/resource/pubmed/id/9037451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-4-1
pubmed:abstractText
The DNA damaging effect of different concentrations of methotrexate, 6-mercaptopurine, 6-thioguanine and cisplatin was tested by nucleoid sedimentation in pokeweed mitogen (PWM)-stimulated lymphocytes of 16 healthy persons in vitro. The examined persons show an individual variation of DNA damage demonstrating individual differences in DNA repair. The method can be used to identify persons with a low DNA repair capacity, and possible cytogenetic side effects of cytostatic drugs can be calculated before starting a cancer therapy. In clinical practice the use of cytostatic drugs is limited because of the side effects on normal tissues. The cancer therapist can improve a cytostatic therapy when he obtains information about possible DNA damage of cytostatic drugs in cells of the patient at the beginning of the therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Detection of DNA damage in stimulated human lymphocytes after adding cytostatic drugs in vitro. A model to demonstrate individual damage rates.
pubmed:affiliation
Clinic of Anesthesiology, University of Mainz, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't