Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-3-20
pubmed:abstractText
NM23 is a protein associated with tumor progression, expressed in all tissues and in human tumors. Reduced expression of NM23.H1 is related to high incidence of lymph node and distant metastasis or to poor prognosis of the patient in several human malignant tumors. In this study we analyze NM23 expression in non-neoplastic mammary tissues surrounding the tumoral lesions, in human mammary carcinomas and in lymph node metastasis. Our analysis shows that NM23.H1 expression is lower in the mammary cells surrounding the tumor than in the tumor itself. In the primary tumors we observed a negative trend between degree of local invasion and level of NM23.H1 expression. A further decrease of NM23.H1 was detected in the invasive tumors that metastasized to axillary lymph nodes and in the metastasis. NM23.H2 was always more highly expressed than NM23.H1, and reduced expression of NM23.H1 but not NM23.H2 was concordant with the presence of lymph node metastasis or local invasiveness of the primary tumor. A positive correlation between NM23.H1 mRNA content and cell growth rate of breast tumor cells has been confirmed. However, this trend was not maintained in cancer cells from tumors that metastasized to axillary lymph nodes and in metastatic cells; in these 2 situations the NM23.H1 mRNA content varied without any relationship to the proliferative rate of the cells. In addition, in comparison with the initial tumor, the metastatic cell population showed a strong decrease of NM23.H1 expression and increased proliferative activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-11
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9036878-Breast Neoplasms, pubmed-meshheading:9036878-Cell Division, pubmed-meshheading:9036878-Disease Progression, pubmed-meshheading:9036878-Female, pubmed-meshheading:9036878-Humans, pubmed-meshheading:9036878-Lymphatic Metastasis, pubmed-meshheading:9036878-Monomeric GTP-Binding Proteins, pubmed-meshheading:9036878-NM23 Nucleoside Diphosphate Kinases, pubmed-meshheading:9036878-Necrosis, pubmed-meshheading:9036878-Neoplasm Invasiveness, pubmed-meshheading:9036878-Neoplasm Metastasis, pubmed-meshheading:9036878-Nucleoside-Diphosphate Kinase, pubmed-meshheading:9036878-RNA, Messenger, pubmed-meshheading:9036878-Regression Analysis, pubmed-meshheading:9036878-Transcription, Genetic, pubmed-meshheading:9036878-Transcription Factors, pubmed-meshheading:9036878-Tumor Markers, Biological
pubmed:year
1997
pubmed:articleTitle
NM23 gene expression in human breast carcinomas: loss of correlation with cell proliferation in the advanced phase of tumor progression.
pubmed:affiliation
Institute of Pathology, University of Pisa, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't