Linked Life Data

9035421

Source:http://linkedlifedata.com/resource/pubmed/id/9035421

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1997-3-10
pubmed:abstractText
Hyperacute xenogeneic rejection is partly initiated by the binding of performed natural antibodies on the recipient's vascular endothelium. In this study, isotypic suppression of IgM in the recipient was conducted in the guinea pig-to-rat combination. Anti-IgM HIS 40 and 56 monoclonal antibodies were injected intraperitoneally in rats (n = 3) (Group 1). Control animals were rats (n = 13) treated by PBS (Group 2). Guinea pig hearts were implanted heterotopically in all rats. Depletion of circulating IgM in the recipient was assessed by ELISA. The circulating and splenic B-lymphocyte population was scanned by FACS analysis. Isotypic suppression was very effective for the depletion of circulating IgM in Group 1 rats (alpha < 0.01) as assessed by ELISA. Similarly, the rate of circulating and splenic B-lymphocytes was significantly decreased in treated animals (alpha < 0.01). However, the graft survival in Group 1 (14 +/- 6.9 min) was not different from that observed in Group 2 (15.4 +/- 5 min). Isotypic suppression of IgM in the recipient did not delay hyperacute xenogenic rejection in the guinea pig-to-rat combination. The prevention of hyperacute rejection must therefore be based on the various mechanisms of this phenomenon.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-3944
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
524-31
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Attempt at preventing hyperacute xenogenic rejection by isotopic suppression of IgM in the recipient].
pubmed:affiliation
Laboratoire d'lmmunologie, Hôpital Cochin, Paris.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Review