Linked Life Data

9034352

Source:http://linkedlifedata.com/resource/pubmed/id/9034352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1997-5-6
pubmed:abstractText
The collagen cross-linking compound deoxypyridinoline (DPD) has been shown to be a marker of bone resorption and skeletal growth in children. However, the original method for the determination of total (i.e. free and peptide-bound) DPD (tDPD) in urine samples is technically demanding. The recent development of a simple enzyme-linked immunosorbent assay for the quantification of immunogenic DPD (iDPD) in urine samples might be a more convenient technique. Yet, it is unclear at present whether iDPD is equal to tDPD as an index of bone resorption and skeletal growth. Therefore, using 24-h urines from 144 healthy children and adolescents aged 4-19 years, we established reference ranges for the daily urinary excretion of iDPD. A close correlation was found between the daily urinary excretion of iDPD and tDPD related to body weight (r = 0.87, p < 0.001). In 72 subjects aged 4-18 years, the daily excretion of iDPD normalized to body weight was highly significantly correlated with growth velocity (r = 0.70, p < 0.001). We conclude that the enzyme-linked immunosorbent assay for urinary iDPD appears to provide a good index of bone resorption and growth in healthy children.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0036-5513
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
715-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Urinary immunoreactive deoxypyridinoline in children and adolescents: variations with age, sex and growth velocity.
pubmed:affiliation
Children's Hospital, University of Cologne, Germany.
pubmed:publicationType
Journal Article