rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1997-3-14
|
pubmed:abstractText |
Soluble cytokine receptors modulate the activity of their cognate ligands. Interleukin (IL)-6 in association with the soluble IL-6 receptor (sIL-6R) can activate cells expressing the gp130 signal transducer lacking the specific IL-6R. To investigate the function of the IL-6-sIL-6R complex in vivo and to discriminate the function of the IL-6-sIL-6R complex from the function of IL-6 alone, we have established a transgenic mouse model. Double-transgenic mice coexpressing IL-6 and sIL-6R were generated and compared with IL-6 and sIL-6R single-transgenic mice. The main phenotype found in IL-6-sIL-6R mice was a dramatic increase of extramedullary hematopoietic progenitor cells in liver and spleen but not in the bone marrow. In IL-6 single-transgenic mice and sIL-6R single-transgenic mice no such effects were observed. The high numbers of hematopoietic progenitor cells were reflected by a strong increase of peripheral blood cell numbers. Therefore, activators of the gp130 signal transducer like the IL-6-IL-6R complex may represent most powerful stimulators for extramedullary hematopoietic progenitor cells. gp130 activators may become important for the expansion of hematopoietic progenitor cells in vivo and in vitro.
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1382711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1528870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1655258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1698556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1729694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-1854882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2139075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2141631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2163835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2208278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2261637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2444978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2529343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2569739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2788034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2798426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-2821154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-3136546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-3496134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7513204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7535932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7539136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7566171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7574495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7739518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7789261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7862649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7895162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-7984236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8002928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8127368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8137821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8182142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8293462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8353278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8379461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8405437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8436181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8497320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8543798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8548812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8552649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8574965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8666898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8683127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8710878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8755479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8755571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8757135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8834766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034153-8999038
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0022-1007
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
185
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
755-66
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:9034153-Humans,
pubmed-meshheading:9034153-Animals,
pubmed-meshheading:9034153-Mice,
pubmed-meshheading:9034153-Body Weight,
pubmed-meshheading:9034153-Spleen,
pubmed-meshheading:9034153-Liver,
pubmed-meshheading:9034153-Cell Division,
pubmed-meshheading:9034153-Cell Differentiation,
pubmed-meshheading:9034153-Organ Size,
pubmed-meshheading:9034153-Cell Separation,
pubmed-meshheading:9034153-Hematopoietic Stem Cells
|