| pubmed-article:9034149 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C1824677 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0178587 | lld:lifeskim |
| pubmed-article:9034149 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:9034149 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9034149 | pubmed:dateCreated | 1997-3-14 | lld:pubmed |
| pubmed-article:9034149 | pubmed:abstractText | CD3-zeta/eta-deficient mice have small thymuses containing cells that show a profound reduction in the surface levels of T cell receptors and terminate their differentiation at the CD4+CD8+ stage. Rather unexpectedly, CD3- or very low single positive T cells accumulate over time in the spleen and lymph nodes of CD3-zeta/eta-deficient mice after a process dependent on MHC expression. Fusion of these peripheral T cells with a CD3-zeta-positive derivative of the BW5147 TCR-alpha-/beta- thymoma resulted in hybridomas that do express an heterogeneous set of T cell receptor alpha/beta dimers at their surface and at density comparable to those found in hybridomas derived from wild-type peripheral T cells. We have investigated the specificities of these T cell receptors using spleen cells from congenic and mutant mouse strains, and showed that the majority of them readily recognized self-MHC class I or class II molecules. These results demonstrate that by increasing the density and/or output of the T cell receptors expressed in peripheral T cells, one can confer them with the capacity to respond to normal density of self-MHC molecules. | lld:pubmed |
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| pubmed-article:9034149 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9034149 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9034149 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9034149 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9034149 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9034149 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9034149 | pubmed:author | pubmed-author:TANY CYC | lld:pubmed |
| pubmed-article:9034149 | pubmed:author | pubmed-author:MalissenBB | lld:pubmed |
| pubmed-article:9034149 | pubmed:author | pubmed-author:ArdouinLL | lld:pubmed |
| pubmed-article:9034149 | pubmed:author | pubmed-author:MalissenMM | lld:pubmed |
| pubmed-article:9034149 | pubmed:author | pubmed-author:GilletAA | lld:pubmed |
| pubmed-article:9034149 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9034149 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:9034149 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:9034149 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9034149 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9034149 | pubmed:pagination | 707-15 | lld:pubmed |
| pubmed-article:9034149 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9034149 | pubmed:meshHeading | pubmed-meshheading:9034149-... | lld:pubmed |
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| pubmed-article:9034149 | pubmed:meshHeading | pubmed-meshheading:9034149-... | lld:pubmed |
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| pubmed-article:9034149 | pubmed:meshHeading | pubmed-meshheading:9034149-... | lld:pubmed |
| pubmed-article:9034149 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9034149 | pubmed:articleTitle | The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex. | lld:pubmed |
| pubmed-article:9034149 | pubmed:affiliation | Centre d'Immunologie, Institut National de la Sante et de la Recherche Medicale-Centre National de Recherche Scientifique de Marseille-Luminy, France. | lld:pubmed |
| pubmed-article:9034149 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9034149 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12503 | entrezgene:pubmed | pubmed-article:9034149 | lld:entrezgene |
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