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rdf:type |
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lifeskim:mentions |
umls-concept:C0024518,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0178587,
umls-concept:C0205148,
umls-concept:C0205171,
umls-concept:C0205307,
umls-concept:C0332285,
umls-concept:C0439855,
umls-concept:C0567416,
umls-concept:C1446409,
umls-concept:C1824677
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pubmed:issue |
4
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pubmed:dateCreated |
1997-3-14
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pubmed:abstractText |
CD3-zeta/eta-deficient mice have small thymuses containing cells that show a profound reduction in the surface levels of T cell receptors and terminate their differentiation at the CD4+CD8+ stage. Rather unexpectedly, CD3- or very low single positive T cells accumulate over time in the spleen and lymph nodes of CD3-zeta/eta-deficient mice after a process dependent on MHC expression. Fusion of these peripheral T cells with a CD3-zeta-positive derivative of the BW5147 TCR-alpha-/beta- thymoma resulted in hybridomas that do express an heterogeneous set of T cell receptor alpha/beta dimers at their surface and at density comparable to those found in hybridomas derived from wild-type peripheral T cells. We have investigated the specificities of these T cell receptors using spleen cells from congenic and mutant mouse strains, and showed that the majority of them readily recognized self-MHC class I or class II molecules. These results demonstrate that by increasing the density and/or output of the T cell receptors expressed in peripheral T cells, one can confer them with the capacity to respond to normal density of self-MHC molecules.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1346064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1346934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1358623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1476600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1531041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1547489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1690625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1705867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1710780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-1909605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-2112266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-2428504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-2558022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-2778316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-2784543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-3260923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7520000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7577806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7688481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7734423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7741032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-7916949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8046340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8103746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8112294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8131747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8223444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8223495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8245790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8282319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8294874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8402907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8490660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8598039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8642273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8658175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8666889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8676065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8717505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8779719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8793999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9034149-8920241
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
185
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
707-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9034149-Animals,
pubmed-meshheading:9034149-Antigens, CD3,
pubmed-meshheading:9034149-Hybridomas,
pubmed-meshheading:9034149-Major Histocompatibility Complex,
pubmed-meshheading:9034149-Mice,
pubmed-meshheading:9034149-Mice, Inbred C57BL,
pubmed-meshheading:9034149-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:9034149-T-Lymphocytes
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pubmed:year |
1997
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pubmed:articleTitle |
The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex.
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pubmed:affiliation |
Centre d'Immunologie, Institut National de la Sante et de la Recherche Medicale-Centre National de Recherche Scientifique de Marseille-Luminy, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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