Linked Life Data

9034010

Source:http://linkedlifedata.com/resource/pubmed/id/9034010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-4-30
pubmed:abstractText
We recently reported an association between the long repeat allele of the dopamine D4 exon III receptor polymorphism and a human personality dimension, novelty seeking, as measured by the tridimensional personality questionnaire (TPQ), a personality instrument designed by Cloninger to reflect heritable facets of human temperament. The D4 receptor polymorphism (D4DR) accounts for only a small percent of the variance for this trait, suggesting that additional genes influence both novelty seeking as well as the other temperaments that are inventoried by the Cloninger TPQ. In the current investigation, we examined, in the original cohort of 120 normal volunteers, two additional coding region polymorphisms, a glycine to serine substitution in the dopamine D3 receptor (D3DR) and a cysteine to serine substitution in the 5-HT2C serotonin receptor (HTR2C). Three-way analysis of variance (TPQ score grouped by D4DR, D3DR and 5-HT2C) demonstrated that reward dependence and persistence scores were significantly reduced by the presence of the less common 5-HT2Cser polymorphism. The effect of the serine substitution in this X-linked serotonin receptor polymorphism on reward dependence was also observed when male and female subject groups were separately analyzed. There was also a significant interaction between the two dopamine receptor polymorphisms and the serotonin polymorphism on reward dependence. In particular, the effect of the 5-HT2C polymorphism on reward dependence was markedly accentuated in individuals who had the long version of the D4DR exon III repeat polymorphism. When present in the same individual, the 5-HT2C and dopamine receptor polymorphisms account for 30% of the observed variance for persistence (RD2) and 13% of the variance for reward dependence scores (RD134). However, the number of subjects with both less common D4DR and 5-HT2C polymorphisms is small, underscoring the importance of verifying this interaction in a larger cohort.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0148-7299
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9034010-Adult, pubmed-meshheading:9034010-Cohort Studies, pubmed-meshheading:9034010-Cysteine, pubmed-meshheading:9034010-DNA Primers, pubmed-meshheading:9034010-Exploratory Behavior, pubmed-meshheading:9034010-Female, pubmed-meshheading:9034010-Genetic Markers, pubmed-meshheading:9034010-Genotype, pubmed-meshheading:9034010-Humans, pubmed-meshheading:9034010-Israel, pubmed-meshheading:9034010-Male, pubmed-meshheading:9034010-Polymerase Chain Reaction, pubmed-meshheading:9034010-Polymorphism, Genetic, pubmed-meshheading:9034010-Questionnaires, pubmed-meshheading:9034010-Receptor, Serotonin, 5-HT2C, pubmed-meshheading:9034010-Receptors, Dopamine D2, pubmed-meshheading:9034010-Receptors, Dopamine D3, pubmed-meshheading:9034010-Receptors, Dopamine D4, pubmed-meshheading:9034010-Receptors, Serotonin, pubmed-meshheading:9034010-Reward, pubmed-meshheading:9034010-Serine, pubmed-meshheading:9034010-Temperament
pubmed:year
1997
pubmed:articleTitle
5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms.
pubmed:affiliation
Research Laboratory, S. Herzog Memorial Hospital, Jerusalem, Israel.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't