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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-5-2
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pubmed:abstractText |
Serum levels of soluble CD44 variant proteins including sequences encoded by exon v5 and exon v6 (sCD44v5, sCD44v6) were determined in patients with inflammatory rheumatic diseases: 56 with rheumatoid arthritis (RA+) and 31 with miscellaneous inflammatory rheumatic diseases (MIRD). There were very significantly higher serum levels of sCD44v5 and sCD44v6 in patients with RA+ than in those with MIRD (RA+ to MIRD: sCD44v5: 81 +/- 54 ng/ml to 33 +/- 13 ng/ml; sCD44v6: 237 +/- 124 ng/ml to 166 +/- 53 ng/ml; both P << 0.001). In RA+ elevated serum levels of sCD44v5 were correlated with the inflammatory activity of disease. In 17 patients with RA+ three or four follow-up measurements of sCD44v5 were performed within 6 months. The development of sCD44v5 serum levels reflected the clinical course of disease in the patients investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0172-8172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9032816-Adult,
pubmed-meshheading:9032816-Aged,
pubmed-meshheading:9032816-Aged, 80 and over,
pubmed-meshheading:9032816-Antibodies, Antinuclear,
pubmed-meshheading:9032816-Antigens, CD44,
pubmed-meshheading:9032816-Arthritis, Rheumatoid,
pubmed-meshheading:9032816-Blood Cell Count,
pubmed-meshheading:9032816-Blood Sedimentation,
pubmed-meshheading:9032816-C-Reactive Protein,
pubmed-meshheading:9032816-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:9032816-Female,
pubmed-meshheading:9032816-Hemoglobins,
pubmed-meshheading:9032816-Humans,
pubmed-meshheading:9032816-Immunoglobulin M,
pubmed-meshheading:9032816-Immunosuppressive Agents,
pubmed-meshheading:9032816-Male,
pubmed-meshheading:9032816-Middle Aged,
pubmed-meshheading:9032816-Rheumatoid Factor,
pubmed-meshheading:9032816-Treatment Outcome
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pubmed:year |
1997
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pubmed:articleTitle |
Serum levels of soluble CD44 variant isoforms are elevated in rheumatoid arthritis.
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pubmed:affiliation |
Institute for Laboratory Medicine, Donauspital, Vienna, Austria.
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pubmed:publicationType |
Journal Article
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