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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1997-4-29
|
| pubmed:abstractText |
Maturational changes in the specific compliance could potentially contribute to the development or clinical presentation of respiratory diseases in infants and children. Changes in the specific compliance during development and its structural basis have been well characterized, but changes in bronchial compliance and the mechanisms involved have received little attention. Semistatic pressure-volume curves were generated for isolated bronchial segments from late-term foetal, immature and adult pigs. A small number of bronchi from human infants were also studied. The amount of cartilage in the bronchial wall of pigs of different ages was measured histologically, and morphometric changes in the wall of inflated bronchi were investigated. The specific compliance of bronchi approximately halved from 1 to 4 weeks of age. No change in specific compliance was observed either between 4 week old and adult pigs, or between late-term foetal and 1 week old pigs. Changes in the total wall and cartilage areas did not correlate with changes in specific compliance. Inflation to 20 cmH2O transmural pressure reduced the total wall area of bronchi from 1 week old pigs. Significant changes in bronchial distensibility occur during the early postnatal period. These changes in specific compliance are not caused by an increase in the amount of cartilage. The increase in luminal volume during inflation of bronchial segments occurs, partially, by compression of the airway wall against the cartilage layer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0903-1936
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
27-34
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9032487-Age Factors,
pubmed-meshheading:9032487-Animals,
pubmed-meshheading:9032487-Animals, Newborn,
pubmed-meshheading:9032487-Bronchi,
pubmed-meshheading:9032487-Cartilage,
pubmed-meshheading:9032487-Compliance,
pubmed-meshheading:9032487-Cryopreservation,
pubmed-meshheading:9032487-Humans,
pubmed-meshheading:9032487-Image Processing, Computer-Assisted,
pubmed-meshheading:9032487-Infant,
pubmed-meshheading:9032487-Inhalation,
pubmed-meshheading:9032487-Lung,
pubmed-meshheading:9032487-Lung Compliance,
pubmed-meshheading:9032487-Lung Volume Measurements,
pubmed-meshheading:9032487-Pressure,
pubmed-meshheading:9032487-Respiration,
pubmed-meshheading:9032487-Respiratory Mechanics,
pubmed-meshheading:9032487-Respiratory Tract Diseases,
pubmed-meshheading:9032487-Swine
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Bronchial compliance and wall structure during development of the immature human and pig lung.
|
| pubmed:affiliation |
Dept of Physiology, The University of Western Australia, Nedlands, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|