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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-5-12
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pubmed:abstractText |
To investigate the toxicity of beta-amyloid protein, a component of the senile plaques in Alzheimer's disease, it was infused into the cerebral ventricle of rats for 14 days by a mini-osmotic pump. Performances in the water maze and passive avoidance tasks in beta-amyloid protein-treated rats were impaired. Choline acetyltransferase activity significantly decreased in the hippocampus both immediately and 2 weeks after the cessation of the infusion. However, the learning impairment was recoverable 2 weeks after cessation of the infusion. Both immediately and 2 weeks after the cessation of the infusion, glial fibrillary acidic protein immunoreactivity increased. Furthermore, beta-amyloid protein altered the staining in the nuclei of hippocampal cells for only 2 weeks after the cessation. These results suggest that beta-amyloid protein produces some damage in the central nervous system in vivo.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-5198
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:9032134-Amyloid beta-Peptides,
pubmed-meshheading:9032134-Animals,
pubmed-meshheading:9032134-Avoidance Learning,
pubmed-meshheading:9032134-Choline O-Acetyltransferase,
pubmed-meshheading:9032134-Corpus Striatum,
pubmed-meshheading:9032134-Frontal Lobe,
pubmed-meshheading:9032134-Glial Fibrillary Acidic Protein,
pubmed-meshheading:9032134-Hippocampus,
pubmed-meshheading:9032134-Immunohistochemistry,
pubmed-meshheading:9032134-Injections, Intraventricular,
pubmed-meshheading:9032134-Male,
pubmed-meshheading:9032134-Maze Learning,
pubmed-meshheading:9032134-Nerve Degeneration,
pubmed-meshheading:9032134-Parietal Lobe,
pubmed-meshheading:9032134-Rats,
pubmed-meshheading:9032134-Rats, Wistar
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pubmed:year |
1997
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pubmed:articleTitle |
Continuous infusion of beta-amyloid protein into the rat cerebral ventricle induces learning impairment and neuronal and morphological degeneration.
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pubmed:affiliation |
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Tsuruma-cho, Showa-ku, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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