| pubmed-article:9030880 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0038170 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0011615 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0206527 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9030880 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:9030880 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9030880 | pubmed:dateCreated | 1997-3-11 | lld:pubmed |
| pubmed-article:9030880 | pubmed:abstractText | We have examined the cell-mediated immunity (CMI) to Staphylococcus aureus (S. aureus) and Staphylococcal enterotoxin B (SEB) in peripheral blood mononuclear cells (PBMC) from children with atopic dermatitis (AD) and from non-atopic child controls by measurement of proliferative responses and production of the cytokines IFN-gamma and IL-4. PBMC from children with AD showed significantly higher proliferative responses to both S. aureus (P < 0.01) and SEB (P < 0.05). Despite this enhanced proliferation, production of IFN-gamma in response to S. aureus (P < 0.001) and SEB (P < 0.01) from these PBMC was significantly diminished. In contrast, PBMC from children with AD were significantly more likely to produce IL-4 in response to S. aureus (P < 0.01). These findings demonstrate in vitro heightened CMI to S. aureus in children with AD, and implicate S. aureus as a potent inflammatory stimulant. Impaired IFN-gamma production to S. aureus in vivo may result in failure to eradicate S. aureus from skin. The organism's persistence on skin would contribute to inflammation by causing continued T cell activation and release of pro-inflammatory mediators. | lld:pubmed |
| pubmed-article:9030880 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9030880 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9030880 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9030880 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9030880 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:9030880 | pubmed:author | pubmed-author:CampbellD EDE | lld:pubmed |
| pubmed-article:9030880 | pubmed:author | pubmed-author:KempA SAS | lld:pubmed |
| pubmed-article:9030880 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9030880 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:9030880 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9030880 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9030880 | pubmed:pagination | 392-7 | lld:pubmed |
| pubmed-article:9030880 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
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| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:meshHeading | pubmed-meshheading:9030880-... | lld:pubmed |
| pubmed-article:9030880 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9030880 | pubmed:articleTitle | Proliferation and production of interferon-gamma (IFN-gamma) and IL-4 in response to Staphylococcus aureus and staphylococcal superantigen in childhood atopic dermatitis. | lld:pubmed |
| pubmed-article:9030880 | pubmed:affiliation | Department of Immunology, Royal Children's Hospital, Melbourne, Australia. | lld:pubmed |
| pubmed-article:9030880 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9030880 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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